Turn off the Real-time protection toggle switch. Under the 'Virus & threat protection settings' section, click the Manage settings option. Search for Windows Security and click the top result to open the app.To disable the real-time protection on Microsoft Defender, use these steps: How to disable Microsoft Defender protection using Windows Security How to disable Microsoft Defender protection using PowerShell.How to disable Microsoft Defender protection using Windows Security.In this Windows 10 guide, we'll walk you through the steps to temporarily disable the real-time protection on Microsoft Defender Antivirus. VPN Deals: Lifetime license for $16, monthly plans at $1 & more